HSL PRECISION AMR PROJECTS

HSL has received funding from DHSC to carry out research into improving our current antimicrobial resistance diagnostic pathways

Affiliated with the HSL Infection Sciences and Molecular Pathology departments and clinician researchers across UCLH and Royal Free Trusts, the AMR pipeline is designed to support pathogen sequencing, metagenomics, microbiome and RNA sequencing for the purpose of evaluating and translating new diagnostic methods for use in clinical pathology. In addition, the facility will support local and national clinical trials as well as third party activity from pharmaceutical, contract research and other industrial partner organisations.

Four HSL led projects have been fully funded. The following videos provide a summary of these projects and make part of HSL’s patient and public involvement strategy:


Developing a diagnostic WGS pathway for the characterisation of Aspergillus species isolated from patients at risk of Invasive fungal infection: with focus on cyp51A gene profiling for the detection of azole resistance

Dr Rebecca Gorton

Developing a diagnostic WGS pathway for the investigation of duodenal and gastric biopsies for the presence of H. pylori antibiotic resistance markers.

Dr Alan Williams

Development of a WGS laboratory diagnostic pathway for the identification of M. genitalium and subsequent detection of relevant resistance targets.

Dr Paul Grant

Developing a diagnostic WGS pathway for the characterisation of multi-drug resistant bacteria in outbreak situations.

Dr Alan Williams

HSL is a partnership between The Doctors Laboratory, Royal Free London NHS Foundation Trust (the Royal Free London) and University College London Hospitals NHS Foundation Trust (UCLH)

Health Services Laboratories
Health Services Laboratories
Health Services Laboratories