HSL Precision Antimicrobial Resistance (AMR) projects
HSL has received funding from DHSC to carry out research into improving our current antimicrobial resistance (AMR) diagnostic pathways
Affiliated with the HSL Infection Sciences and Molecular Pathology departments and clinician researchers across UCLH and Royal Free Trusts, the AMR pipeline is designed to support pathogen sequencing, metagenomics, microbiome and RNA sequencing for the purpose of evaluating and translating new diagnostic methods for use in clinical pathology. In addition, the facility will support local and national clinical trials as well as third party activity from pharmaceutical, contract research and other industrial partner organisations.
HSL Research Portal: Precision AMR
Four HSL led projects have been fully funded. The following videos provide a summary of these projects and make part of HSL’s patient and public involvement strategy.
Developing a diagnostic whole genome sequencing (WGS) pathway for the characterisation of Aspergillus species isolated from patients at risk of Invasive fungal infection: with focus on cyp51A gene profiling for the detection of azole resistance
Dr Rebecca Gorton
Developing a diagnostic whole genome sequencing (WGS) pathway for the investigation of duodenal and gastric biopsies for the presence of H. pylori antibiotic resistance markers.
Dr Alan Williams
Development of a whole genome sequencing (WGS) laboratory diagnostic pathway for the identification of M. genitalium and subsequent detection of relevant resistance targets.
Dr Paul Grant MBE
Developing a diagnostic whole genome sequencing (WGS) pathway for the characterisation of multi-drug resistant bacteria in outbreak situations.
Dr Alan Williams